Effect of 5-HT and postsynaptic 5-HT1 A on the mood and recogniztion of the repeated restraint stress in rats.
- Author:
Jian-song ZHOU
1
;
Lingjiang LI
;
Xia CAO
;
Xiang-hui ZHANG
;
Wei-hui LI
;
Ze-xuan LI
Author Information
1. Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Affect;
physiology;
Animals;
Male;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Receptor, Serotonin, 5-HT1A;
physiology;
Recognition, Psychology;
physiology;
Restraint, Physical;
Serotonin;
physiology;
Stress, Psychological;
metabolism;
psychology;
Synaptosomes;
chemistry
- From:
Journal of Central South University(Medical Sciences)
2008;33(4):305-311
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the role of 5-HT and postsynaptic 5-HT1A receptors in the stress adaptation.
METHODS:p-PCA was used to deplete the 5-HT in rats. The 5-HT1A agonist 8-OH-DPAT and antagonist WAY100635 were used to determine the effect of postsynaptic 5-HT1A receptors on the ratso behaviors in the Elevated Plus-Maze test, the Forced Swimming test, and the Morris Water Maze test.
RESULTS:Compared with the intact rats, the 5-HT depleted rats showed more seriously anxious behaviors in the Elevated Plus-Maze test and more obvious learned helplessness in the Forced Swimming test. After having been stressed the 5-HT depleted rats showed significantly impaired learning and memory compared with the intact rats according to Morris Water Maze test. Activation of postsynaptic 5-HT1A receptors by 8-OH-DPAT in the 5-HT depleted rats or the 5-HT depleted stress rats significantly decreased the symptoms of anxiety and learned helplessness behaviors which were prevented by the treatment of WAY100635. The 8-OH-DPAT and WAY100635 had no obvious effect on the 5-HT depletion or 5-HT depleted stress rats in the Morris Water Maze test.
CONCLUSION:Deficiency of 5-HT in rats may suppress its ability to stress adaptation. Activation of post-synaptic 5-HT1A receptors can attenuate the anxiety and depressive behavior symptoms, and facilitate rats to adapt stress.
