-2548G/A functional polymorphism in the promoter region of leptin gene and antipsychotic agent-induced weight gain in schizophrenic patients: a study of nuclear family-based association.
- Author:
Xiao-dong MOU
1
;
Zhi-jun ZHANG
;
Xiang-rong ZHANG
;
Jia-bo SHI
;
Jing SUN
Author Information
1. Department of Neurology, Affiliated Zhongda Hospital, Southeast University, Nanjing, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Antipsychotic Agents;
therapeutic use;
Family Health;
Female;
Genotype;
Humans;
Leptin;
genetics;
Male;
Polymerase Chain Reaction;
Polymorphism, Restriction Fragment Length;
Promoter Regions, Genetic;
genetics;
Schizophrenia;
drug therapy;
genetics;
physiopathology;
Weight Gain;
drug effects;
genetics
- From:
Journal of Central South University(Medical Sciences)
2008;33(4):316-320
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate whether there is association between the-2548G/A functional polymorphism in the promoter region of leptin gene and weight gain following antipsychotic agents (APS) acute treatment in schizophrenic patients.
METHODS:Eight-four Chinese Han untreated schizophrenia patients in 70 nuclear families were recruited. The polymorphism of leptin gene was determined with PCR-RFLP technique. Body weight was measured in the patients on admission the and after 10 weeks treatment with risperidone or chlorpromazine.
RESULTS:There was an average (8.00+/-6.13)% increases in baseline weight after the 10 week treatment. There were significant differences in the distribution of allele frequencies (chi2=4.031, P=0.045) between the patients with weight changed >or=7% and <7% subgroups. Family-based association analysis further confirmed the above significant finding by transmission disequilibrium test but not by quantitative trait transmission disequilibrium test.
CONCLUSION:The finding confirms that the-2548G/A polymorphism in promoter region of leptin gene is associated with APS-induced weight gain.
