Effect of apoB polymorphism on plasma lipid levels and cerebral hemorrhage in Changsha Han Chinese.
- Author:
Zhong-Yang HU
1
;
Le ZHANG
;
Qi-Dong YANG
Author Information
1. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Apolipoproteins B;
genetics;
Cerebral Hemorrhage;
blood;
genetics;
China;
ethnology;
Female;
Genetic Predisposition to Disease;
Humans;
Lipoproteins;
blood;
Male;
Middle Aged;
Polymorphism, Genetic;
genetics
- From:
Journal of Central South University(Medical Sciences)
2008;33(6):494-499
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effect of apoB polymorphism on plasma lipid levels and cerebral hemorrhage in (CH) Changsha Han Chinese.
METHODS:One hundred thirty CH patients and 100 normal people were involved. C7673T polymorphism of apoprotein B was analyzed by PCR-restriction fragment length polymorphism (PCR-PFLP); and the triglyceride(TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL), and low density lipoprotein-cholesterol(LDL) levels were examined by oxidase method. The serum level of lipoprotein(a) was determined by immunology method.
RESULTS:(1) Allele T frequencies of apoB C7673T in CH patients and the control group were 0.108 and 0.040, respectively. Allele T frequencies of apoB C7673T in the CH patients were significantly higher than those in the control group (P< 0.01). (2) In the CH patients, the levels of TC and LDLjC of the T/C gene type were significantly higher than those of the C/C gene type, while the levels of HDLjC of the T/C gene type were significantly lower than those of the C/C gene type (P< 0.05).
CONCLUSION:ApoB C7673T polymorphism may be related to cerebral hemorrhage, and the changing blood lipid level may increase the susceptibility of CH.
