Spontaneous abortion and changes of estrogen receptors and progesterone receptors in the endometria of patients with polycystic ovary syndrome.
- Author:
Xiao-Bo SHI
1
;
Jing ZHANG
;
Shu-Xin FU
Author Information
1. Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Abortion, Spontaneous;
etiology;
metabolism;
Adult;
Endometrium;
metabolism;
Female;
Humans;
Polycystic Ovary Syndrome;
complications;
metabolism;
Pregnancy;
Receptors, Estrogen;
metabolism;
Receptors, Progesterone;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2008;33(6):518-522
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the relationship between the spontaneous abortion and changes of estrogen receptors (ER) and progesterone receptors (PR) in the endometria of patients with polycystic ovary syndrome (PCOS).
METHODS:Thirty-two patients who suffered PCOS combined with infertilitas feminis were enrolled in a experimental group,and 20 patients with tubal infertilitas feminis having the corresponding time period as a control group. The expressions of ER and PR in the endometria were observed by pathological examination and immunohistochemical staining.
RESULTS:The expressions of ER and PR in the glands and interstitium of endometrial in the PCOS group were significantly lower than those of the tubal infertilitas feminis group (P=0.004,P=0.001). The expressions of ER and PR in the PCOS group in the glands organ and interstitium of endometrial among 3 different periods were not significantly different (P>0.05). The expressions of ER in the glands of endometrium in the spontaneous abortion group were significantly lower than those of the non-spontaneous abortion group (P=0.02), but there was no statistical difference between the two groups in the interstitium of endometria (P>0.05). The expression of PR in the glands interstitium of endometria showed no statistical difference between the spontaneous abortion group and the non-spontaneous abortion group (P>0.05).
CONCLUSION:The decrease of ER and PR of endometrial in the PCOS patients, may be a reason for spontaneous abortion, and the cyclical irregularity of ER and PR in the PCOS patients is another cause of spontaneous abortion.
