Functional genomics of nasopharyngeal carcinoma susceptibility/suppressor gene.
- Author:
Xiao-Ling LI
1
;
Ming-Hua WU
;
Gui-Yuan LI
Author Information
1. Cancer Research Institute, Central South University, Changsha 410078, China.
- Publication Type:Journal Article
- MeSH:
Biomarkers, Tumor;
Cell Cycle Proteins;
genetics;
Chromosomal Proteins, Non-Histone;
genetics;
Genomics;
methods;
Glycoproteins;
genetics;
Humans;
Membrane Proteins;
genetics;
Nasopharyngeal Neoplasms;
genetics;
metabolism;
pathology;
Phosphoproteins;
genetics;
RNA, Long Noncoding;
RNA, Untranslated;
Tumor Cells, Cultured;
Tumor Suppressor Proteins;
genetics
- From:
Journal of Central South University(Medical Sciences)
2008;33(7):553-558
- CountryChina
- Language:Chinese
-
Abstract:
There is obvious allele disequilibrium in nasopharyngeal carcinoma at chromosome 3p, 9p, 6q, 11q, 13q and 14q. Nasopharyngeal carcinoma (NPC) susceptibility/suppressor gene candidates were obtained by molecular biology methods,such as cDNA representational difference ana-lysis. The functional research of NPC susceptibility/ suppressor gene candidates indicated: (1) The increased expression of Cx contributed to obstacles of gap junctional intercellular communication (GJIC), and resulted an aberration of GJIC; (2) BRD7, a transcript factor, was associated with cell cycle regulation; (3) NAG7,an estrogen receptor repressor, inhibited the invasive potential of human NPC cells by regulating ERalpha expression and the H-ras/p-c-Raf and JNK/AP-1/MMP1 signaling pathways; (4) NGX6, a metastasis-associated protein, can negative-regulate EGF/Ras/MAPK signaling transduction pathway, and interact with ezrin protein to inhibit invasion and metastasis of NPC cells; (5) SPLUNC1, a secreted protein, can inhibit the bacterium clone formation, and is an innate immune molecule. These data will lay an important foundation for the NPC mechanism.
