Non-alcoholic fatty liver, high sensitivity C reactive protein and insulin resistance.
- Author:
Wei-Dong ZHOU
1
;
Ya-Ling YANG
;
Zhi-Hong CHE
Author Information
1. Department of Endocrinology of Second Xiangya Hospital, Institute of Metabolism and Endocrinology, Diabetes Center, Metabolic Syndrome Research Center, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Adult;
C-Reactive Protein;
metabolism;
China;
epidemiology;
Fatty Liver;
epidemiology;
metabolism;
Female;
Humans;
Insulin Resistance;
Male;
Middle Aged;
Regression Analysis;
Risk Factors
- From:
Journal of Central South University(Medical Sciences)
2008;33(7):565-570
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the relationship among non-acoholic fatty liver disease (NAFLD), high sensitivity reactive C protein (hsCRP) and insulin resistance.
METHODS:Workers of an enterprise in Changsha for health examination in Second Xiangya Hospital from October to December, 2006, NAFLD group (243 patients) and a control group without fatty liver disease (361 patients) were randomly drawn. Questionnaire, physical examination, fasting plasma glucose, serum lipid-profile, alanine aminotransferase (ALT),blood uric acid, and abdominal ultrasonographic examination were undertaken in the 2 groups.
RESULTS:The moderate NAFLD group had significantly higher hsCRP concentration and homeostasis model assessment of insulin resistance (HOMA-IR) as compared with the mild NAFLD group (P<0.01). The patients with insulin resistance had significantly higher hsCRP concentration and ALT level compared with NAFLD patients without insulin resistance (P<0.05). The NAFLD patients were divided into 2 groups (low and high) according to the hsCRP concentration (<1 mg/L or > or = 1 mg/L). Compared with the low concentration group, the odds ratio of the high concentration group for prevalence of NAFLD was 5.937(P<0.001). Multi-factor logistic regression analysis demonstrated that NAFLD was independently correlated with hsCRP or HOMA-IR after adjustment for sex, age and metabolic components (OR=2.044, 7.896,P<0.01).
CONCLUSION:NAFLD is closely correlated with hsCRP and HOMA-IR. Insulin resistance and elevated hsCRP concentration are the independent risk factors for the presence of NAFLD.
