Genetic polymorphism of 15 STR on chromosome 2 and 11 in Shaanxi Han people in China.
- Author:
Xiao-Wei SHI
1
;
Feng-Ling REN
;
Dong GENG
Author Information
1. Department of Public Health, Medical School of Xioan Jiaotong University, Xioan 710061, China.
- Publication Type:Journal Article
- MeSH:
Adult;
China;
ethnology;
Chromosomes, Human, Pair 11;
genetics;
Chromosomes, Human, Pair 2;
genetics;
Female;
Gene Frequency;
Humans;
Male;
Microsatellite Repeats;
genetics;
Polymorphism, Genetic
- From:
Journal of Central South University(Medical Sciences)
2008;33(7):587-591
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the genetic polymorphism of 15 short tandem repeat(STR)loci on chromosome 2 and chromosome 11 in Shaanxi Han people in China.
METHODS:Fluorescence-based gene scan technique was used to examine the genetic polymorphism of 15 STR loci in 175 unrelated individuals from Chinese Han population in Shannxi province.
RESULTS:The number of alleles D2S335, D2S396, D2S338, D2S2382, D2S305, D2S151, D2S2368, D2S391,D11S912, D11S4090, D11S4147, D11S4190, D11S4149, D11S4126, and D11S4094 was 11,11,11,10,8,8,9,12 ,7,11,8,10,5,5, and 6. The distribution of allele frequencies of the 15 STR was consistent with Hard-Weinberg equilibrium (P > 0.05). Heterozygosity (H) value was 0.4216 to approximately 0.8517, the average power of discrimination (DP) was 0.6568 to approximately 0.9598, polymorphism information content (PIC) was 0.4078 to approximately 0.8366, and probability of paternity exclusion (EPP) was 0.3135 to approximately 0.8537.
CONCLUSION:The 15 STR loci have relatively high genetic polymorphism in Shaanxi Han population, which provides the genetic structure of Chinese Han groups, and is also useful in anthropology and forensic science.
