Effect of valsartan on postprandial plasma inflammatory factors in patients with essential hypertension.
- Author:
Ling LIU
1
;
Shui-Ping ZHAO
;
Hong-Nian ZHOU
;
Dan-Yan XU
;
Ji-Xiang LI
Author Information
1. Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China. feliuling@medmail.com.cn
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Antihypertensive Agents;
therapeutic use;
C-Reactive Protein;
metabolism;
Dietary Fats;
adverse effects;
Female;
Humans;
Hypertension;
blood;
drug therapy;
Male;
Middle Aged;
P-Selectin;
blood;
Tetrazoles;
therapeutic use;
Triglycerides;
blood;
Valine;
analogs & derivatives;
therapeutic use;
Valsartan
- From:
Journal of Central South University(Medical Sciences)
2008;33(9):809-813
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effect of valsartan on the concentrations of plasma inflammatory factors after a high-fat meal in patients with essential hypertension in very short time.
METHODS:Fifty hypertensive patients and 25 healthy controls were studied. Patients randomly accepted lacidipine 4 mg/d (lacidipine group) or valsartan 80 mg/d (valsartan group) for 1 week. The concentrations of plasma lipid profiles, high-sensitivity C-reactive protein (hsCRP) and soluble P-selectin were measured in fasting state and at 4 h after a single high-fat meal in all subjects at baseline and in patients after 1 week.
RESULTS:The concentrations of postprandial plasma hsCRP and soluble P-selectin significantly increased after a high-fat meal in patients (P < 0.05), as compared with those at fasting levels, but not in the controls. The postprandial plasma triglyceride concentrations significantly increased in the healthy controls (P < 0.05), but were lower than those in hypertensive patients (P < 0.01). Postprandial change in plasma concentration of triglyceride was significantly correlated with those of log (hsCRP) (r = 0.344)and soluble P-selectin (r = 0.432), respectively (n = 75, both P < 0.01). Lipids profiles did not change significantly after 1 week. There was no significant difference between the fasting and postprandial plasma concentrations of either hsCRP or soluble P-selectin in valsartan group, while the postprandial increments of inflammatory factors were still significant in the lacidipine group.
CONCLUSION:High-fat meal can induce postprandial inflammation response in patients with essential hypertension. Valsartan effectively attenuates this postprandial inflammation response within a very short time.
