Effect of content of hepatitis B virus DNA in the serum on the pathologic change in hepatitis B virus associated-glomerulonephritis.
- Author:
Wei JIANG
1
;
Li-qiu LIU
Author Information
1. Department of Nephrology, Attached Hospital of Medical School, Qingdao University, Shangdong Qingdao 266003,China. jw-qy@163.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
DNA, Viral;
blood;
Female;
Glomerulonephritis, Membranous;
pathology;
virology;
Hepatitis B virus;
physiology;
Hepatitis B, Chronic;
complications;
virology;
Humans;
Male;
Middle Aged;
Virus Replication
- From:
Journal of Central South University(Medical Sciences)
2008;33(9):857-860
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the correlation between the content of hepatitis B virus DNA(HBV-DNA) in the serum and the pathologic change in hepatitis B virus associated-glomerulonephritis (HBV-GN).
METHODS:Forty one HBV-GN patients were divided into 3 groups by the content of HBV-DNA in the serum:low replicate group,midrange replicate group, and high replicate group. The relationship with the content of HBV-DNA in the serum and pathologic stage or change was analyzed in 35 membranous glomerulopathy patients; Effect of the content of hepatitis B virus DNA in the serum on HBVAg deposition in glomeruli of kidney was examined by immunohistochemistry; Effect of HBVAg deposition on pathologic change was observed in membranous glomerulopathy patients.
RESULTS:With the multiplication of HBV-DNA in the serum, the pathologic lesion was aggravating from Stage I to Stage III in membranous glomerulopathy patients; the deposition of HBVAg in glomeruli of kidney was increasing; with the increasing of deposition of HBVAg in glomeruli of kidney, the pathologic lesion was aggravating in membranous glomerulopathy patients.
CONCLUSION:With the multiplication of HBV-DNA in the serum, the deposition of HBVAg in glomeruli of kidney increases, and the pathologic lesion aggravates, which have significant correlation.
