Relation of tumor associated macrophages and mast cells of tumor interstitial and angiogenesis in non-small cell lung cancer.
- Author:
Wen ZOU
1
;
Tie-hui HU
Author Information
1. Department of Oncology, Second Xiangya Hospital, Central South University, Changsha 410011, China. zouwen29w@126.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Non-Small-Cell Lung;
blood supply;
pathology;
Female;
Humans;
Leukocyte Count;
Lung Neoplasms;
blood supply;
pathology;
Macrophages;
cytology;
Male;
Mast Cells;
cytology;
Middle Aged;
Neovascularization, Pathologic;
Prognosis
- From:
Journal of Central South University(Medical Sciences)
2007;32(6):1037-1041
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect tumor microvessel count (MVC), tumor associated macrophage (TAM) and Mast cell (MC) counts, and to explore their correlation and the clinical significance in non-small cell lung cancer (NSCLC).
METHODS:Immunohistochemical staining (ABC method) was used to measure MVC and TAM and MC counts in 40 cases of NSCLC tissues and 10 cases of normal pulmonary tissues as contrast.
RESULTS:The counts of microvessel, TAMs, and MCs in the NSCLC tissues were apparently higher than those of the normal tissues, and these counts increased with the development of T stage and clinical stage, metastasis of the tumor, and the reduction of the patient survival time. The positive correlation was showed among the counts of microvessel, TAMs, and MCs.
CONCLUSION:Tumor interstitial infiltrating inflammatory cells, TAMs and MCs can cooperatively promote the tumor angiogenesis,which associates with the development, invasion, metastasis and prognosis of NSCLC.
