Changes of plasma CD40L and PAPP-A in patients with acute coronary syndrome after the PCI operation.
- Author:
Xu-ping LI
1
;
Sheng-hua ZHOU
;
Jian-zhun TANG
;
Qi-ming LIU
;
Zhen-fei FANG
;
Xin-qun HU
;
Tao ZHOU
;
Xiang-qian SHEN
;
Shu-shan QI
Author Information
1. Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China. lixp0711@126.com
- Publication Type:Journal Article
- MeSH:
Acute Coronary Syndrome;
blood;
therapy;
Adult;
Aged;
Aged, 80 and over;
Angina, Stable;
blood;
CD40 Ligand;
blood;
Female;
Humans;
Male;
Middle Aged;
Percutaneous Coronary Intervention;
Postoperative Period;
Pregnancy-Associated Plasma Protein-A;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2007;32(6):1098-1101
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the changes and significance of plasma CD40L and pregnancy-associated plasma protein-A (PAPP-A) in acute coronary syndrome (ACS) patients after percutaneous coronary intervention (PCI) operation.
METHODS:According to the occurrence of primary heart events or restenosis 6 months after the PCI, 68 patients were divided into the ACS group and the stable angina pectoris (SAP) group. Plasma CD40L and PAPP-A after the PCI operation were measured and compared. Thirty-six patients underwent repeated angiography after the PCI. Their baseline and follow up angiograms were compared by quantitative coronary angiography to assess the incidence of restenosis.
RESULTS:CD40L and PAPP-A after the PCI operation were higher in the ACS group than that in the SAP group.The group having primary heart events within 6 months had higher level of PAPP-A after the PCI. The group having restenosis 6 months had higher level of PAPP-A after the PCI. The change of later loss index of coronary artery lumen diameter was correlated with PAPP-A level after the PCI.
CONCLUSION:CD40L and PAPP-A were higher in the ACS group, indicating the possible mechanism by which CD40L facilitates the plaque rupture via up-regulating the PAPP-A expression.Plasma PAPP-A level after the PCI possibly for cases the occurrence of primary heart events or restenosis within 6 months.
