Measurement of activated clotting time during cardiopulmonary bypass in infective endocarditis patients.
- Author:
Ling JIANG
1
;
Jie-Feng YU
Author Information
1. Department of Cardiothoracic Suergery, Second Xiangya Hospital, Central South University, Changsha 410011, China. zxb960@sohu.com
- Publication Type:Journal Article
- MeSH:
Adult;
Anticoagulants;
therapeutic use;
Cardiopulmonary Bypass;
Dose-Response Relationship, Drug;
Drug Monitoring;
methods;
Endocarditis;
surgery;
Female;
Heparin;
therapeutic use;
Heparin Antagonists;
therapeutic use;
Humans;
Intraoperative Care;
methods;
Male;
Middle Aged;
Protamines;
therapeutic use;
Whole Blood Coagulation Time
- From:
Journal of Central South University(Medical Sciences)
2007;32(1):167-169
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the proper dosage of heparin and protamin in treating the patients with infective endocarditis (IE) during the operation.
METHODS:Activated clotting time (ACT) was measured during and after cardiopulmonary bypass (CPB) in 30 patients with IE and 30 patients with rheumatic heart disease (RHD) respectively.
RESULTS:The dosage of heparin before bypass in IE group was significantly higher than that of RHD group (P<0.05); the dosage of protamin for neutralization after bypass in IE group was significantly higher than that of RHD group (P<0.05); the ratio of protamin and heparin were 0.76 +/-0.23 in IE group and 0.74 +/-0.12 in RHD group (P>0.05).
CONCLUSION:The dosage of protamin should be increased to 3 mg/kg as the heparin is over 400 U/kg before CPB in the patient with IE, but the ratio of protamin and heparin will not be obviously changed.
