Identification of the origin of marker chromosome by comparative genomic hybridization.
- Author:
Lu ZHOU
1
;
Ling-Qian WU
;
De-Sheng LIANG
;
Qian PAN
;
Zhi-Gao LONG
;
He-Ping DAI
;
Juan LI
;
Fang CAI
;
Kun XIA
;
Jia-Hui XIA
Author Information
1. National Laboratory of Medical Genetics of China, Xiangya Hospital, Central South University, Changsha, China.
- Publication Type:Case Reports
- MeSH:
Chromosome Aberrations;
Chromosome Deletion;
Chromosomes, Human, Pair 13;
genetics;
Female;
Genome, Human;
Humans;
In Situ Hybridization, Fluorescence;
methods;
Karyotyping;
Nucleic Acid Hybridization;
methods
- From:
Journal of Central South University(Medical Sciences)
2007;32(2):264-267
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To identify the origin of the marker chromosome in a patient with chromosome aberration, and to provide the precise genetic diagnosis.
METHODS:Comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH) were performed to detect the known small marker chromosome in this patient.
RESULTS:The small marker chromosome originated from chromosome 13 pter->q12.
CONCLUSION:CGH and FISH can be used to detect the small marker chromosome, which is convenient and quick in detecting the origin of small marker chromosome.
