High myopia and retinal ultrastructure of albino guinea-pigs.
- Author:
Jie-Yue WANG
1
;
Shuang-Zhen LIU
;
Xin WEI
;
Xiao-Ying WU
;
Xing-Ping TAN
Author Information
1. Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Albinism;
complications;
Animals;
Guinea Pigs;
Melanins;
biosynthesis;
Microscopy, Electron, Scanning;
Myopia;
congenital;
etiology;
metabolism;
Random Allocation;
Retina;
metabolism;
pathology;
ultrastructure;
Skin Pigmentation
- From:
Journal of Central South University(Medical Sciences)
2007;32(2):282-287
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the relationship between melanin synthesis and the congenital high myopia of albino guinea-pigs.
METHODS:Twelve albino guinea-pigs and 12 pigmented guinea-pigs of 220~250 grams (aged 5~6 weeks) were chosen at random. The eyes were examined with retinoscopy, A-scan ultrasonography and vernier caliper. The retinal structures were examined with light and electronic microscope.
RESULTS:The diopter was -19.17 D in albino guinea-pigs and +0.63 D in pigmented guinea-pigs on average. Compared with the pigmented guinea-pigs, the axial dimensions of the albino guinea-pigs were elongated. There was significant difference between the albino guinea-pigs and the pigmented guinea-pigs. The retinal thickness, pigment granules and membrane disc of the outer segment of the visual cells decreased in the albino guinea-pigs, and the membrane disc space became narrow. The normal retinal thickness, plenty of pigment granules , membrane disc and wide membrane disc space could be observed in the pigmented guinea-pigs.
CONCLUSION:Albino guinea-pigs have high myopia, and pigmented guinea pigs have light hyperopia. There are structural differences in the retina between albino guinea-pigs and pigmented guinea-pigs. The abnormity of albino guinea-pigs provides optical foundation for its high myopia.
