Effect of mannitol on vasoactive substances.
- Author:
Xiao-Ping ZHU
1
;
Ji-An LUO
;
Fu-You LIU
;
You-Ming PENG
Author Information
1. Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China. zhuxiaoping0508@hotmail.com
- Publication Type:Journal Article
- MeSH:
Acute Kidney Injury;
blood;
chemically induced;
physiopathology;
Angiotensins;
blood;
Animals;
Atrial Natriuretic Factor;
blood;
Dose-Response Relationship, Drug;
Endothelins;
blood;
Male;
Mannitol;
administration & dosage;
toxicity;
Rabbits;
Random Allocation;
Renal Circulation;
drug effects;
Renin-Angiotensin System;
drug effects
- From:
Journal of Central South University(Medical Sciences)
2007;32(2):333-336
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the changes of vasoactive substances in rabbits administered with mannitol at different dosages and to investigate the mechanism of acute renal failure (ARF) induced by massive mannitol administration.
METHODS:Eighteen healthy male New Zealand rabbits were randomly divided into 3 groups: a minor mannitol group (n=6, mannitol 8 g/kg within 2 hours), a control group (n=6, saline of the same volume), and a massive mannitol group with free water taking (n=6, mannitol 40~60 g/kg within 3 days). The changes of renin, angiotensin-I (ang-I), angiotensin-II (ang-II), endothelin (ET), and atrial natriuretic factor(ANF) in the serum were observed.
RESULTS:No significant changes in the renin, ang-I, ang-II, ET, and ANF in the serum were found between the minor mannitol group and the saline control group (P> 0.05). In the massive mannitol group with free water taking, renin, ang-I, and ang-II in the serum increased significantly compared with the other 2 groups; ET in the serum decreased significantly compared with the saline control group (P< 0.05); no significant changes in the ANF in the serum were found compared with the other 2 groups(P> 0.05).
CONCLUSION:ARF induced by massive mannitol administration is associated with a significant change of vasoactive substances.
