Correlation between Sonographic Severity and Biochemical Markers of Synovium and Cartilage in Knee Osteoarthritis Patients.
- Author:
Young Ok JUNG
1
;
Hae Rim KIM
;
Hyo Jong KANG
;
Seung Ah YOO
;
Jong Myoung NAH
;
Chul Soo CHO
;
Ho Youn KIM
;
Wan Uk KIM
Author Information
1. Department of Internal Medicine, Division of Rheumatology, Catholic University of Korea. wan725@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Knee osteoarthritis;
Biochemical markers;
Ultrasonography
- MeSH:
Biomarkers*;
Cartilage*;
Enzyme-Linked Immunosorbent Assay;
Humans;
Hyaluronic Acid;
Joints;
Knee Joint;
Knee*;
Osteoarthritis, Knee*;
Osteocalcin;
Osteophyte;
Synovial Membrane*;
Ultrasonography*
- From:The Journal of the Korean Rheumatism Association
2004;11(1):44-51
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Ultrasonography has benefit in detecting soft tissue abnormalities within the joints, which cannot be assessed by conventional X-ray. In this study, we investigated the relationship between soft tissue and/or bony abnormalities on ultrasonography and biochemical markers of synovium and cartilage in knee osteoarthritis (OA) patients METHODS: Fifty-one knee OA patients who fulfilled the ACR criteria were enrolled in this study. Knee ultrasonography was performed in affected knee joints with a 12 MHz linear probe to assess the presence of effusion, synovial proliferation, capsular distension, length of osteophytes, and thickness of cartilage. At the same time, the serum levels of hyaluronic acid (HA) and cartilage oligomeric protein (COMP) were measured by ELISA and serum osteocalcin levels were determined by RIA. RESULTS: The patients with longer medial osteophytes showed higher levels of serum HA and COMP than those with shorter ones. Serum HA levels were significantly higher in patients with larger amount of effusion and/or synovial proliferation, suggesting inflammatory changes within the joint, than those without. In addition, the severity of capsular distention was also correlated well with serum HA and COMP levels. However, the length of lateral osteophytes and thickness of femoral cartilage were not correlated with serum HA or COMP levels. Serum osteocalcin levels did not show any association with above ultrasonographic parameters, either. CONCLUSIONS: Using knee ultrasonography, we demonstrated that serum HA and COMP levels were elevated in more severe OA patients than less severe patients. This result suggests that detailed pathologic changes in the soft tissue and/or bone of OA joints on ultrasonography are being directly reflected to biochemical markers measured in the peripheral blood.
