Genomic instability in nasopharyngeal carcinoma.
- Author:
He-qing LI
1
;
Yu-min ZHU
;
Jiang-bo CHEN
;
Guo-lin TAN
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Base Sequence;
Chromosome Deletion;
Chromosomes, Human, Pair 3;
genetics;
Chromosomes, Human, Pair 6;
genetics;
DNA Mutational Analysis;
Genomic Instability;
Humans;
Molecular Sequence Data;
Mutagenesis, Insertional;
Nasopharyngeal Neoplasms;
genetics;
pathology;
Polymerase Chain Reaction;
methods;
Prognosis;
Survival Analysis
- From:
Journal of Central South University(Medical Sciences)
2007;32(3):417-421
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the effect of genomic instability on prognostics in nasopharyngeal carcinoma.
METHODS:Genomic instability was assessed by inter-simple sequence repeats polymerase chain reaction (inter-SSR PCR) in 38 patients with nasopharyngeal carcinoma. Characterization and verification of band alterations shared in different tumors were carried out by sequencing and nest PCR.
RESULTS:Thirty-one (81.6%) of the 38 patients showed genomic altercations, and genomic instability index ranged 0 to 16.2 percent. A gain-based genomic damage shared in 6 tumors was identified on chromosome 6q27. Genomic alteration was significantly more in patients less than 5-year survival than those with more than 5-year survival (P<0.05).
CONCLUSION:Genomic instability can be an early event marker in carcinogenesis of nasopharyngeal carcinoma. Aggravation of genomic alterations is a poor prognosis for cancer recovery.
