Expression and activity change of angiotensin converting enzyme in the placenta of preeclampsia.
- Author:
Ling YU
1
;
Yu-ping MA
;
Yi-ling DING
Author Information
1. Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Cross-Sectional Studies;
Female;
Humans;
In Situ Hybridization;
Peptidyl-Dipeptidase A;
blood;
genetics;
metabolism;
Placenta;
enzymology;
Pre-Eclampsia;
enzymology;
Pregnancy;
RNA, Messenger;
biosynthesis;
genetics
- From:
Journal of Central South University(Medical Sciences)
2007;32(3):498-502
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of angiotensin converting enzyme (ACE) in the pathogenesis of preeclampsia.
METHODS:A cross-sectional study was conducted with 42 pregnant women in the following categories: 30 cases of preeclampsia (mild preeclampsia, n=15; severe preeclampsia, n=15), and normal pregnancy (control group,n=12). The expression and localization of ACE mRNA in the placenta of the 3 groups were respectively examined by in situ hybridization. Ultraviolet radiation colorimetry was used to detect the activity of ACE in the placenta tissue homogenate and the mothers' serum in the 3 groups.
RESULTS:The expression of ACE mRNA was found in the endothelial cells of villus and trophoblasts in the placenta. The positive index of ACE mRNA in the placenta of preeclampsia(3.12+/-0.94) was higher than that in the normal pregnancies(1.65+/-0.67) (P<0.05), and there was significant difference between severe preeclampsia and mild preeclampsia (P<0.05). The levels of ACE activity in the placenta tissue homogenate and the maternal serum of preeclampsia were higher than those in the normal pregnancies (P<0.05), and there was significant difference between severe preeclampsia and mild preeclampsia (P<0.05). The placenta tissue homogenate ACE activity was correlated with ACE activity of the maternal serum (r=0.781,P<0.05).
CONCLUSION:The expression and activity of local ACE in the placenta tissue may play an important role in preeclampsia and contribute to the development of preeclampsia.
