Mechanism and protective effect of glossy ganoderma decoction on the activities of RNA polymerase in hepatocyte of rabbits with Amanita mushroom poisoning.
- Author:
Gui-Lin XIAO
1
;
Ning YANG
;
Chun-Hu ZHANG
;
Sui-Yu HU
Author Information
1. Department of Emergency, Xiangya Hospital, Central South University, Changsha 410008, China. xiaoguilinxy@126.com
- Publication Type:Journal Article
- MeSH:
Alanine Transaminase;
metabolism;
Amanita;
Animals;
DNA-Directed RNA Polymerases;
metabolism;
Ganoderma;
Hepatocytes;
drug effects;
metabolism;
Liver;
drug effects;
metabolism;
Male;
Medicine, Chinese Traditional;
Mushroom Poisoning;
drug therapy;
physiopathology;
Rabbits
- From:
Journal of Central South University(Medical Sciences)
2007;32(4):637-640
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the mechanism of glossy ganoderma decoction in Amanita mushroom poisoning.
METHODS:Twenty male New Zealand white rabbits were randomly divided into 4 groups, including a normal control, a model poison group, and 2 treatment groups (different doses of glossy ganoderma decoction). The activities of hepatocyte RNA polymerase were measured by ultraviolet spectrophotometry and liver function were measured.
RESULTS:The activities of hepatocyte RNA polymerase of the model group significantly decreased, and those of the 2 treatment groups were significantly higher than those of the model group. There was a dose-dependent manner between the 2 treatment groups ( all Ps<0.01), and the differences of liver function test including total bilirubin (TBIL), direct bilirubin (DB), total bile acid (TBA), and alanine aminotransferase (ALT) in the 4 groups were significant (P<0.01).
CONCLUSION:Glossy ganoderma decoction may protect the liver from Amanita mushroom poisoning. Its mechanism may be related to the increase of the activities of hepatocyte RNA polymerase.
