Clinical and pathologic features of melanocytic lesion of the central nervous system.
- Author:
Ning ZHANG
1
;
Zun-Jing LIU
;
Gang LI
;
Bo XIAO
;
Yun-Hai LIU
;
Guo-Liang LI
;
Bing-Qing LU
;
Jing-Hui LIANG
Author Information
1. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China. zhnxyyy@vip.sina.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Child;
Female;
Humans;
Male;
Melanosis;
pathology;
Meningeal Neoplasms;
pathology;
Middle Aged;
Nervous System Diseases;
pathology;
Neurocutaneous Syndromes;
pathology;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2007;32(4):713-717
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical and pathologic features of melanocytic lesion of the central nervous system.
METHODS:We analyzed the clinical features, neuroimages, and operational and neuropathological findings of 2 patients of neurocutaneous melanosis and 4 patients of primary leptomeningeal melanoma.
RESULTS:All the 6 patients had the common clinical features of intracranial hypertension and epilepsy. Brain CT and MRI showed abnormal signals. More melanin pigment nevi were found on the skin of the 2 patients subjected to neurocutaneous melanosis. The other 4 patients subjected to primary leptomeningeal melanoma had no melanin pigment nevus on the skin, but the brain section displayed positive meningeal melanoma.
CONCLUSION:Intracranial hypertension and epilepsy are the main clinical manifestations of melanocytic lesion of the central nervous system, and cutaneous lesion and radiological findings are very important for the diagnosis.
