Clinical significance of the expression of the RCAS1 mRNA and protein in astrocytic tumors.
- Author:
Chen-fu SHEN
1
;
Xian-rui YUAN
;
Zhi-qiang QIN
Author Information
1. Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Antigens, Neoplasm;
genetics;
metabolism;
Astrocytoma;
genetics;
metabolism;
Brain Neoplasms;
genetics;
metabolism;
Child;
Child, Preschool;
Female;
Humans;
Male;
Middle Aged;
RNA, Messenger;
genetics;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2007;32(5):836-839
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the mRNA and protein expressions of RCAS1 in human astrocytic tumors, and to explore the relation between their expression and the genesis and development of tumor.
METHODS:The RCAS1 mRNA expression in human astrocytic tumors was evaluated by RT-PCR, and the RCAS1 protein expression was studied by immunohistochemical staining.
RESULTS:The quantities of RCAS1 mRNA expression between diffusive astrocytoma(Grade II) and anaplastic astrocytoma(Grade III), anaplastic astrocytoma and glioblastoma(Grade IV) were significantly different(P<0.05), while the expression scores of RCAS1 protein were different only between the anaplastic astrocytoma and glioblastoma(P<0.01). RCAS1 protein expression was positively correlated with the tumor grade (r=0.573,P<0.001). The RCAS1 protein was not detected in normal brain tissues by immunohistochemical staining.
CONCLUSION:The RCAS1 expression is related to the histological grade of astrocytic tumor. In astrocytic tumors, the RCAS1 expression is regulated transcriptionally and posttranscriptionally.
