Contrast enhanced power Doppler in evaluating the angiogenesis in hepatocellular carcinoma.
- Author:
Ji-dong XIAO
1
;
Shou-rong SHEN
;
Rui-zhen LI
;
Ping ZHOU
;
Wen-hui ZHU
Author Information
1. Department of Ultrasound, Third Xiangya Hospital, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Carcinoma, Hepatocellular;
blood supply;
diagnostic imaging;
Contrast Media;
Female;
Humans;
Liver Neoplasms;
blood supply;
diagnostic imaging;
Male;
Middle Aged;
Neovascularization, Pathologic;
Ultrasonography, Doppler;
methods
- From:
Journal of Central South University(Medical Sciences)
2007;32(5):840-844
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the role of contrast enhanced power Doppler in evaluating tumor angiogenetic activity.
METHODS:Thirty-two patients with hepatocellular carcinoma were analysed. Flow signals of hepatocellular carcinoma were observed by power Doppler imaging after the injection of contrast agent, and then the relative perfusion rate and blood flow were assessed. The microvessel density (MVD) and vascular endothelial growth factor(VEGF) were assessed by immunohistochemical method. The relationship between the relative perfusion rate,blood flow, MVD,VEGF was studied.
RESULTS:The relative perfusion rate in the tissues with positive expression of VEGF was significantly higher than that in the tissues with negative expression of VEGF in hepatocellular carcinoma. There was correlation between the relative perfusion rate, blood flow grade and MVD(P<0.05). The expression of VEGF was positively related to the relative perfusion rate and blood flow grade(P<0.05).
CONCLUSION:Contrast enhanced power Doppler is useful in evaluating the tumor angiogenetic activity.
