Biotoxicology and biodynamics of silica nanoparticle.
- Author:
Zhi-gang XUE
1
;
Shai-hong ZHU
;
Qian PAN
;
De-sheng LIANG
;
Yu-mei LI
;
Xiong-hao LIU
;
Kun XIA
;
Jia-hui XIA
Author Information
1. National Key Laboratory of Medical Genetics, Central South University, Changsha 410078, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Female;
Male;
Materials Testing;
Mice;
Nanostructures;
toxicity;
Rats;
Silicon Dioxide;
pharmacokinetics;
toxicity;
Tissue Distribution;
Transfection
- From:
Journal of Central South University(Medical Sciences)
2006;31(1):6-8
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the toxicology and biodynamics of silica nanoparticle.
METHODS:The silica nanoparticles were injected into mice through tail vein, and the mice were amphimixised, the urine was collected in different time, variations of pathology in organs and tissues of the mice were detected. At the same time, the silica nanoparticles' distribution in the tissues was observed through electron microscope.
RESULTS:The silica nanoparticles were detected in all tissues and urine of the mice. The injected mice can reproduce as normal.
CONCLUSION:The silica nanoparticles do not have toxicity and can be used in vivo.
