Progression of lipopolysaccharide signal pathway.
- Author:
Yi-xin YANG
1
;
Gui-yuan LI
Author Information
1. Cancer Research Institute, Central South University, Changsha 410078, China.
- Publication Type:Journal Article
- MeSH:
Acute-Phase Proteins;
metabolism;
Carrier Proteins;
metabolism;
Gram-Negative Bacteria;
chemistry;
Lipopolysaccharide Receptors;
metabolism;
Lipopolysaccharides;
pharmacology;
Membrane Glycoproteins;
metabolism;
Mitogen-Activated Protein Kinase Kinases;
metabolism;
NF-kappa B;
physiology;
Signal Transduction
- From:
Journal of Central South University(Medical Sciences)
2006;31(1):141-145
- CountryChina
- Language:Chinese
-
Abstract:
Lipopolysaccharide (LPS) is the major constituents of the outer membrane of Gram-negative bacteria. LPS recognition and signal transmission are key events in the host defense reaction towards Gram-negative bacteria and are associated with many disorders. Multiple signaling pathways are involved in the response to LPS. With the help of LPS-binding protein and CD14, TLR4 binds with LPS, then recruits myeloid differentiation factor 88 and IL-1 receptor-associated kinase, and further phosphorylates and activates TNF receptor associated factor 6 (TRAF6). The activated TRAF6 leads to the activation of transcription factor NF-kappaB and MAP kinase's pathways that involves in LPS-induced cellular responses and the production of proinflammatory cytokines such as TNF-alpha, IL-6 and IL8.
