Inhibitory effect of xipayi mouth rinse on the secretion of IL-6 from human gingival fibroblast induced by lipopolysaccharide.
- Author:
Wufuer HAMULATI
1
;
Yusufu AIBIBAI
;
Liang-jun ZHONG
Author Information
1. Department of Uygur Medicine, Xinjiang Medical University, Urumqi, China.
- Publication Type:Journal Article
- MeSH:
Anti-Inflammatory Agents;
pharmacology;
Cells, Cultured;
Depression, Chemical;
Drugs, Chinese Herbal;
pharmacology;
Fibroblasts;
metabolism;
Gingiva;
cytology;
Humans;
Interleukin-6;
metabolism;
Lipopolysaccharides;
Mouthwashes
- From:
Journal of Central South University(Medical Sciences)
2006;31(3):326-335
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effects of xipayi mouth rinse of different concentrations on the activities of interleukin-6 (IL-6) from human gingival fibroblast (HGF) induced by lipopolysaccharide (LPS).
METHODS:HGF was stimulated with LPS at 25 g/mL, and the radioimmunoassay (RIA) was used to examine the effect of xipayi mouth rinse at 12.5 approximately 200 g/mL on the secretion of IL-6 in the supernatant of the cell culture.
RESULTS:IL-6 secreted by human gingival fibroblast was significantly inhibited by xipayi mouth rinse in a dose dependent manner.
CONCLUSION:Xipayi mouth rinse can inhibit the secretion of IL-6 from HGF induced by LPS, suggesting the anti-inflammatory effect of xipayi mouth rinse to treat and prevent periodontal diseases.
