Effect of prostaglandin E1 on the expression of tissue inhibitor of metalloproteinase-1 in experimental liver fibrosis rats.
- Author:
Shao-jun LIU
1
;
Shou-rong SHEN
;
Xiao-yan WANG
;
Wu-liang TANG
;
Fen WANG
Author Information
1. Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha, China. cslsj169@126.com
- Publication Type:Journal Article
- MeSH:
Alprostadil;
pharmacology;
Animals;
Carbon Tetrachloride;
Carbon Tetrachloride Poisoning;
Female;
Liver Cirrhosis, Experimental;
chemically induced;
metabolism;
Male;
Random Allocation;
Rats;
Rats, Wistar;
Tissue Inhibitor of Metalloproteinase-1;
biosynthesis;
genetics
- From:
Journal of Central South University(Medical Sciences)
2006;31(3):383-386
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of prostaglandin E1 (PGE1) on the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in experimental liver fibrosis rats.
METHODS:The liver fibrosis model was established by carbon tetrachloride. Rats were divided into a control group and PGE1-treated group. The pathological changes of the liver tissue from the two groups, the semi-quantitative analysis of hepatitic activity in HE stain sections, the pathological image quantitative analysis of the fibrosis degree, TIMP-1 positive cells, and the content of collagen were synthetically analysed.
RESULTS:The mark changes of liver pathology in HE stain sections were that the degree of hepatitic activity in the PGE1-treated group was obviously lower than that in the control group (P < 0.05). The fibrosis degree, TIMP-1 positive cells and the collagenous fibers decreased in the PGE1-treated group (P <0.05).
CONCLUSION:PGE1 has an anti-hepatofibrosis effect in the experimental rats, the inflammation of liver is light, and the proliferation of collagenous fibers can be restrained, whose mechanism is probably associated with the suppression of TIMP-1 expression caused by PGE1.
