Influence and significance of intermittent ventilation on lung cytokines during cardiopulmonary bypass.
- Author:
Dian-jun WANG
1
;
Bang-liang YIN
;
Jian-xi LIU
;
Qing-chun ZHANG
;
Chao HONG
;
Long-yu JIN
Author Information
1. Department of Cardiothoracic Surgery, Third Xiangya Hospital, Central South University, Changsha, China. wangdianjun5128@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adult;
Cardiopulmonary Bypass;
Cytokines;
metabolism;
Female;
Humans;
Interleukin-1;
metabolism;
Interleukin-6;
metabolism;
Intermittent Positive-Pressure Breathing;
Lung;
metabolism;
Male;
Middle Aged;
Rheumatic Heart Disease;
physiopathology;
surgery;
Tumor Necrosis Factor-alpha;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2006;31(3):430-433
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the influence and significance of intermittent ventilation on lung cytokines during cardiopulmonary bypass (CPB).
METHODS:Thirty-six patients with rheumatic heart disease (RHD) were divided into 2 groups randomly: Treatment group (n = 18, given intermittent ventilation once every 5 minutes during CPB; control group ( n = 18), no ventilation during CPB. A brochioalveolar lavage was performed at 2 hours after the CPB. The numbers of granulocytes and the contents of IL-1, IL-6, TNF-alpha, and LDH in the brochioalveolar lavage fluids were measured, and lung PaO2/FiO2 were measured preoperatively and at 1 hour, 4 hours, and 8 hours after the CPB termination.
RESULTS:The numbers of granulocytes and the contents of IL-1, IL-6, TNF-alpha, and LDH of the treatment group in the brochioalveolar lavage fluids were significantly lower than those of the control group (P < 0.05), and the lung PaO2/FiO2 of the treatment group at 1 hour, 4 hours, and 8 hours after the CPB termination significantly increased than those of the control group (P < 0.05). A significant decrease of lung PaO2/FiO2 occurred in both groups at 1 hour, 4 hours, and 8 hours after the CPB compared with the same group at the baseline before the CPB (P < 0.01).
CONCLUSION:Intermittent ventilation has protective effects on the lung injury during CPB by decreasing granulocyte adhesion and the level of lung cytokines, alleviating the lung inflammatory reaction and endothelial cell injury.
