General reproductive toxicity assessment in mice exposed to low-level ozone.
- Author:
Zhi-jun ZHOU
1
;
Zheng-shi ZHOU
;
Bai-zheng TANG
Author Information
1. Department of Laboratory Animal, Central South University, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Dose-Response Relationship, Drug;
Female;
Fertility;
drug effects;
Inhalation Exposure;
adverse effects;
Male;
Mice;
No-Observed-Adverse-Effect Level;
Ozone;
toxicity;
Random Allocation;
Reproduction;
drug effects;
Ultraviolet Rays
- From:
Journal of Central South University(Medical Sciences)
2006;31(3):450-452
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the general reproductive toxicity in mice exposed to low-level ozone.
METHODS:Low-level (0.09 approximately 0.18 mg/m3) ozone was created by 15 W ultraviolet light. The mice in 3 experimental groups and a control group were fed in low-level ozone environment or normal environment, respectively, and then the mating experiment was conducted. The pregnancy rate and the weight variations of the female mice were observed. The weight of the live fetuses was observed, and the appearance, bone and internal organs were checked for malformation.
RESULTS:There were no significant differences in any indexes between the experimental groups and the control group.
CONCLUSION:Low-level ozone created by 15 W ultraviolet light may not have reproductive toxicity in mice.
