MICA*008/A5.1 allele and HCMV infection in kidney transplanted donees of Hunan Han nationality.
- Author:
Bai-sheng HUANG
1
;
Qi-zhi LUO
;
Li-xin LI
;
Bing MEI
;
Yi-zhou ZOU
;
Li-xiang WU
;
Ping YU
Author Information
1. Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, China.
- Publication Type:Journal Article
- MeSH:
Alleles;
Antibodies, Viral;
blood;
China;
Cytomegalovirus;
isolation & purification;
Cytomegalovirus Infections;
genetics;
Female;
Genotype;
Histocompatibility Antigens Class I;
genetics;
Humans;
Immunoglobulin M;
blood;
Kidney Transplantation;
adverse effects;
Male
- From:
Journal of Central South University(Medical Sciences)
2006;31(4):479-482
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between MICA*008/A5.1 allele and human cytomegalovirus (HCMV) infection in kidney transplanted donees of Hunan Han nationality.
METHODS:The MICA*008/A5.1 allele based on 91 kidney transplanted donees and 81 unrelated normal individuals of Han nationality in Hunan Province were analyzed by PCR/SSP assay. At the same time, anti-HCMV antibody IgM was detected in the serum by ELISA method.
RESULTS:The positive rate of MICA*008/A5.1 allele was significantly higher in the control group (56.79%) than that in the kidney transplanted donee group (34.07%) (P <0.05). The infection rate of HCMV in those individuals whose genotype was MICA*008/A5.1 (-) was significantly higher than that in the MICA*008/A5.1(+).
CONCLUSION:The individual whose genotype is MICA*008/A5.1 (+) is not liable to HCMV infection, but the individual whose genotype is MICA*008/A5.1 (-) is liable to HCMV infection.
