Effects of xipayi mouth rinse on the DNA synthesis and change of cell cycles of human gingival fibroblast induced by lipopolysaccharide.
- Author:
Yusufu AIBIBAI
1
;
Wufuer HAMULATI
;
Liang-jun ZHONG
Author Information
1. Department of Endocrinology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
- Publication Type:Journal Article
- MeSH:
Cell Cycle;
drug effects;
DNA;
biosynthesis;
Drugs, Chinese Herbal;
pharmacology;
Fibroblasts;
cytology;
metabolism;
Gingiva;
cytology;
Humans;
Lipopolysaccharides;
Mouthwashes;
pharmacology
- From:
Journal of Central South University(Medical Sciences)
2006;31(4):483-486
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effects of xipayi mouth rinse on the DNA synthesis and change of cell cycles of human gingival fibroblast (HGF) induced by lipopolysaccharide(LPS).
METHODS:HGF was stimulated with LPS at 25 mg/L. Flow cytometry was used to examine the effect of xipayi mouth rinse at 25 mg/L on the DNA synthesis and change of HGF cell cycles.
RESULTS:The percentage of HGF in G( 1) phase increased after the cells were induced by LPS, while the percentage of HGF in S phase decreased. Xipayi mouth rinse could ameliorate this phenomenon.
CONCLUSION:Xipayi mouth rinse can significantly ameliorate the inhibitory effect of LPS on the proliferation of HGF, suggesting the anti-inflammatory effect of xipayi mouth rinse in the treatment and prevention of periodontal diseases.
