Therapeutic effects of intraarticular injection of ligustrazine on knee osteoarthritis.
- Author:
Jian-zhong HU
1
;
Cheng-yao LUO
;
Ming KANG
;
Hong-bin LÜ
;
Guang-hua LEI
;
Zhu DAI
Author Information
1. Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410078, China. hjz3734@vip.sina.com.cn
- Publication Type:Journal Article
- MeSH:
Anti-Inflammatory Agents, Non-Steroidal;
administration & dosage;
Female;
Follow-Up Studies;
Humans;
Injections, Intra-Articular;
Male;
Middle Aged;
Osteoarthritis, Knee;
drug therapy;
Pyrazines;
administration & dosage
- From:
Journal of Central South University(Medical Sciences)
2006;31(4):591-594
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the therapeutic effects of intraarticular injection of ligustrazine on knee osteoarthritis (OA).
METHODS:Seventy-one cases of knee osteoarthritis (82 knees) were randomly divided into ligustrazine (LI) group and sodium hyaluronate (SH) group. The patients were intraarticularly injected ligustrazine or sodium hyaluronate once a week for 5 consecutive weeks, and were followed-up for 3 months. Lequesneos protocol for the evaluation of OA severity and activity was used. The therapeutic effects and changes of Lequesneos index were observed after the treatment.
RESULTS:There was significant decrease in Lequesneos index in SH group after the treatment (P<0.01), but not in LI group (P>0.05). Three weeks later, there was significant decrease in Lequesneos index in both groups after the treatment (P<0.01), with no significant difference between SH and LI group (P>0.05). After the 5-week treatment, the efficacy rate of the LI group was 82.1%, and that of the SH group was 87.2%. No serious toxic or side effect was observed during the treatment and the follow-up.
CONCLUSION:Intraarticular injection of ligustrazine has a therapeutic effect on knee OA. No adverse effect is observed, but it needs long time to take effect.
