Level of asymmetric dimethylarginine and carotid atherosclerosis in patients with chronic kidney disease.
- Author:
Wei-ru ZHANG
1
;
Fan-fan HOU
;
Jian-ping NING
;
Xiao-bing YANG
;
Qiang WU
;
Li-jian TAO
;
Ben-mei CHEN
;
Hong-yan LI
;
Lan CHANG
Author Information
1. Division of Nephrology, Xiangya Hospital, Central South University, Changsha 410078, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Arginine;
analogs & derivatives;
blood;
Carotid Artery Diseases;
blood;
etiology;
Female;
Humans;
Kidney Failure, Chronic;
blood;
complications;
therapy;
Male;
Middle Aged;
Nitric Oxide Synthase;
antagonists & inhibitors;
Renal Dialysis
- From:
Journal of Central South University(Medical Sciences)
2006;31(5):621-628
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To determine the association between asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthase, with atherosclerosis in patients with chronic kidney disease (CKD).
METHODS:One hundred thirty-eight CKD patients were enrolled in this study. Serum levels of L-arginine, ADMA, and SDMA were measured by high-performance liquid chromatography (HPLC). Common carotid arteries intimae-medial thickness (CCA-IMT), cross-sectional calculated intimae-medial thickness (cIM area) and atherosclerotic plaque were detected by noninvasive high-resolution B-mode ultrasonography.
RESULTS:Serum levels of ADMA and SDMA were significantly increased in CKD patients (n=138) compared with age matched healthy subjects (n=42, P<0.01). ADMA and SDMA levels increased with the progression of renal dysfunction and were negatively related to creatinine clearance (Ccr) in pre-dialysis patients (r=-0.315, P<0.05; r=-0.426, P<0.01). Serum levels of ADMA and SDMA in dialysis patients (n=74) were significantly higher than those in pre-dialysis patients (P<0.05). Patients with carotid artery plaques showed significantly higher levels of ADMA compared with those without plaques. Serum levels of ADMA closely correlated with the mean IMT (r=0.471, P<0.01) and cIM area value (r=0.430, P<0.01). These correlations remained significant even after adjusting GFR, age, gender ,and other risk factors for atherosclerosis in the multiple regression analysis.
CONCLUSION:Serum levels of ADMA increased with the progression of CKD and may play a role in the pathogenesis of accelerated atherosclerosis in CKD patients.
