Oxidative stress in nitroglycerin tolerance and treatment with 3,4,5,6-tetrahydroxyxanthone.
- Author:
Rui-zheng SHI
1
;
Guo-gang ZHANG
;
Yong-ping BAI
;
Yuan-jian LI
;
Gao-yun HU
;
Jia CHEN
Author Information
1. Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antioxidants;
pharmacology;
Aorta, Thoracic;
cytology;
Cells, Cultured;
Drug Tolerance;
Endothelium, Vascular;
cytology;
Humans;
Male;
Nitroglycerin;
pharmacology;
Oxidative Stress;
Rats;
Rats, Sprague-Dawley;
Reactive Oxygen Species;
metabolism;
Umbilical Veins;
cytology;
Xanthones;
pharmacology
- From:
Journal of Central South University(Medical Sciences)
2006;31(5):650-654
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the relationship between the nitroglycerin tolerance and the stimulation of radical oxygen species (ROS) production, and the therapeutical effect of 3,4,5,6-tetrahydroxyxanthone.
METHODS:Vasodilator responses to nitroglycerin were examined in the isolated thoracic aorta. The contents of ROS,and cGMP were determined in the cultured human umbilical vein endothelial cells.
RESULTS:3,4,5,6-tetrahydroxyxanthone could significantly reduce the inhibition of relaxation by nitroglycerin. 3,4,5,6-tetrahydroxyxanthone could significantly inhibit the ROS increase and increase the cGMP level.
CONCLUSION:Nitroglycerin tolerance is associated with the stimulation of ROS production,and the reversal of nitroglycerin tolerance with 3,4,5,6-tetrahydroxyxanthone is related to the reduction of ROS.
