Effect of cortisol on ischemic preconditioning in rabbit hearts.
- Author:
Hua-shan XU
1
;
Sheng-xi CHEN
;
Wan-jun LUO
;
Qun-ao GAO
;
Yang YANG
Author Information
1. Department of Cardiothoracic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China. xhhh9@hotmail.com
- Publication Type:Journal Article
- MeSH:
Animals;
Creatine Kinase, MB Form;
blood;
Etomidate;
therapeutic use;
Female;
Ischemic Preconditioning, Myocardial;
Male;
Methylprednisolone;
therapeutic use;
Myocardial Reperfusion Injury;
blood;
prevention & control;
Rabbits;
Random Allocation
- From:
Journal of Central South University(Medical Sciences)
2006;31(5):667-670
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the effects of reacting cortisol on ischemic preconditioning (IPC).
METHODS:Thirty rabbits were randomized into ischemic preconditioning (IPC) group, etomidate (Etom) group, ischemic/reperfusion (IR) group, methylprednisolone (MP) group and a control group. The ratios of infarction size versus risk area (Infarct/Risk) were calculated. The elevations of serum CK activity and cTnI concentrations as well as serum cortisol concentrations were measured.
RESULTS:The ratios of Infarct/Risk were 5.9%+/-2.8% for IPC, 11.3%+/-3.6% for Etom, 26.8%+/-4.5% for IR and 18.2%+/-3.7% for MP. The elevations of serum CK activity (U/L) were 255+/-89 for IPC, 314+/-160 for Etom, 855+/-371 for IR and 768+/-404 for MP, the elevations of serum cTnI concentrations (microg/L) were 3.6+/-0.6 for IPC, 5.9+/-2.0 for Etom, 8.1+/-3.6 for IR and 6.1+/-2.3 for MP. Those indicators among groups are all significantly different (P<0.01). Cortisol reacting was markedly diminished in Etom group.
CONCLUSION:A blunted cortisol reaction can markedly undermine the benefit of ischemic preconditioning, methylprednisolone show a certain myocardial protection. Cortisol may play an important role in the IPC process.
