Effect of vasoactive intestinal peptide and epidermal growth factor on the adhesion of eosinophils to bronchial epithelial cells.
- Author:
Xiang LI
1
;
Xiu-mei XING
;
Jian-song ZHANG
;
Yu-rong TAN
Author Information
1. Research Department of Applied Physiology, Medical College, Hunan Normal University, Changsha 410006, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Bronchi;
cytology;
Cell Adhesion;
drug effects;
Cells, Cultured;
Eosinophils;
cytology;
Epidermal Growth Factor;
physiology;
Epithelial Cells;
cytology;
Female;
Intercellular Adhesion Molecule-1;
biosynthesis;
Interleukin-5;
biosynthesis;
Male;
Rabbits;
Vasoactive Intestinal Peptide;
physiology
- From:
Journal of Central South University(Medical Sciences)
2006;31(5):772-781
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of intrapulmonary regulatory peptides on adhesion of eosinophils (EOS) to bronchial epithelial cells (BECs).
METHODS:Two regulatory peptides, namely vasoactive intestinal peptide (VIP) and epidermal growth factor (EGF) were investigated. VIP and EGF were observed on the secretion of ILs and expression of intercellular adhesion molecule-1 (ICAM-1).
RESULTS:VIP and EGF could decrease ILs secretion and ICAM-1 expression.
CONCLUSION:VIP and EGF inhibited the adhesion of EOS to BEC in the inflammatory process to lighten the airway inflammation.
