Pathogenic characters of infected bacteria after liver transplantation.
- Author:
Jian-dang ZHOU
1
;
Shai-hong ZHU
;
Ying CHEN
;
Xin-min NIE
;
Huai-yan PENG
;
Ke CHENG
Author Information
1. Department of Clinical Laboratory, Third Xiangya Hospital, Central South University, Changsha 410013, China. jiandangzhou@126.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Child;
Child, Preschool;
Drug Resistance, Bacterial;
genetics;
Enterobacteriaceae;
drug effects;
enzymology;
isolation & purification;
Enterobacteriaceae Infections;
microbiology;
Female;
Humans;
Infant;
Liver Cirrhosis;
surgery;
Liver Neoplasms;
surgery;
Liver Transplantation;
adverse effects;
Male;
Microbial Sensitivity Tests;
Middle Aged;
Postoperative Complications;
microbiology;
Retrospective Studies;
Vancomycin Resistance;
genetics
- From:
Journal of Central South University(Medical Sciences)
2005;30(4):430-432
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the main pathogens of infection after the liver transplantation and their antibiotic resistant patterns.
METHODS:The main pathogens of infection after the liver transplantation were retrospectively analyzed. Using 3-dimensional tests, ESBLs (extended-spectrum beta-lactamase), and AmpC were detected among the Gram negative bacilli. beta-Lactamase and Van gene in Enterococcus were determined by the standard agar dilution susceptibility tests and Nitrocefin respectively.
RESULTS:The main infected strains were Enterococcus faecalis (15.0%), Enterobacter cloacae (13.9%), fungus (13.3%), and Escherichia coli (10.7%) after the liver transplantation. Among them, 32.4% of Enterobacter cloacae and 36.8% of Escherichia coli produced ESBLs; 33.8% of Enterobacter cloacae and 10.5% of Escherichia coli. produced AmpC beta-lactamases. The detectable rate of VanA gene in Enterococcusfaecalis and Enterococcus faecium was 7.5% and 11.1%; VanB was 3.8% and 7.4%; VanC was 1.3% and 0, respectively.
CONCLUSION:The infection mainly occurs in the intestinal tract after the liver transplantation. The production of ESBLs and AmpC beta-lactamases is the main mechanism of antibiotic resistance. The increased detectable rate of vancomycin-resistant Enterococcus should be paid attention to.
