C-reactive protein level and the correlation between lung function and CRP levels in patients with chronic obstructive pulmonary diseases.
- Author:
Shang-jie WU
1
;
Ping CHEN
;
Xi-nian JIANG
;
Zhi-jun LIU
Author Information
1. Department of Respiratory Diseases, Second Xiangya Hospital, Central South University, Changsha 410011, China. wushangjie@sina.com
- Publication Type:Journal Article
- MeSH:
Adult;
Biomarkers;
C-Reactive Protein;
metabolism;
Female;
Forced Expiratory Volume;
Humans;
Lung;
physiopathology;
Male;
Middle Aged;
Pulmonary Disease, Chronic Obstructive;
blood;
physiopathology;
Respiratory Function Tests;
Vital Capacity
- From:
Journal of Central South University(Medical Sciences)
2005;30(4):444-446
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the changes of C-reactive protein (CRP) level in patients with chronic obstructive pulmonary diseases (COPD) and to analyze the correlation between the lung function and CRP levels.
METHODS:Sputum and serum specimens were obtained from 30 COPD patients diagnosed according to the national criteria. The CRP level was measured by enzyme-linked immunosorbent assays. The lung function indexes such as the forced expiratory volume in one second (FEV1) and the forced expiratory volume in one second/forced vital capacity (FEV1/FVC) were also determined.
RESULTS:The sputum CRP level in COPD patients was 30-50 times higher than that of the health controls. The sputum CRP level in COPD patients is significantly higher than that of serum in these patients (P < 0.05). The correlation between changes of serum and sputum CRP levels and sputum CRP levels was positive (r = 0.625, P < 0.05). The correlations between changes of serum CRP levels and FEV1 were negative (r = -0.610, -0.725, respectively, P < 0.001). And the correlations between changes of serum and sputum CRP levels and FEV1/FVC were negative (r = -0.639, -0.600, respectively, P < 0.05).
CONCLUSION:The CRP may be secreted from the local respiratory tract. The damage of lung function in COPD patients is associated with the increase of CRP level.
