Effects of baisong tablets on the behavior and levels of norepinephrine and dopamine in the brain of stress rats.
- Author:
Wei-Xi SONG
1
;
Sui-Yu HU
;
Chuan-Yuan HUANG
;
Chang-Hua CHEN
;
Zhe WANG
Author Information
1. Institute of Combination of Traditional Chinese Medicine and Western Medicine, Xiangya Hospital, Central South University, Changsha, China. songweixi911@sina.com
- Publication Type:Journal Article
- MeSH:
Animals;
Behavior, Animal;
drug effects;
Brain;
metabolism;
Depression;
drug therapy;
etiology;
metabolism;
Dopamine;
metabolism;
Drugs, Chinese Herbal;
therapeutic use;
Male;
Norepinephrine;
metabolism;
Phytotherapy;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Tablets
- From:
Journal of Central South University(Medical Sciences)
2005;30(5):574-578
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effects of baisong tablets on the behavior and contents of norepinephrine and dopamine in the brain of stress rats.
METHODS:Forty adult Sprague-Dawley male rats were randomly divided into 4 groups: the control group, the depression model group, the baisong tablet group and the fluoxetine group. The depression model was replicated by chronic unpredictable mild stress and single house in 21 days. Ten rats as a group were treated with baisong tablets or fluoxetine hydrochloride. Changes of behaviors were observed by open-field test and the volume of sugar-solution the rat drank in 24 hours. The weight increase was also observed. The levels of norepinephrine and dopamine in the brain in each group were detected with high-pergomance liquid chromatography.
RESULTS:Compared with the model group, baisong tablets could improve the depressive behaviors significantly, and increase the levels of norepinephrine and dopamine in the rat brain.
CONCLUSION:Baisong tablets can improve the depressive behaviors and increase the levels of 5-hydroxytryptaimne and dopamine in the brain of stress rats.
