Effects of simvastatin on TGF-beta system of diabetic rat kidneys.
- Author:
Zhuo-Xiong CHEN
1
;
Min-Xiang LEI
;
Li-Fang ZHU
;
Jun ZHANG
Author Information
1. Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, China. Leimx@126.com
- Publication Type:Journal Article
- MeSH:
Animals;
Diabetes Mellitus, Experimental;
metabolism;
Diabetic Nephropathies;
prevention & control;
Down-Regulation;
Female;
Kidney;
metabolism;
RNA, Messenger;
metabolism;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Receptors, Transforming Growth Factor beta;
metabolism;
Simvastatin;
pharmacology;
Transforming Growth Factor beta;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2005;30(5):593-596
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects and mechanism of renal benefit of simvastatin on diabetic rat kidneys.
METHODS:Twenty STZ-induced SD rats and 10 normal rats were assigned to diabetic rat (DM) group, simvastatin [ 4 mg/( kg x d) ] treatment (S) group and normal control (C) group. Immunohistochemistry, RT-PCR and western-blot were employed to examine the changes of the mRNA and protein expression of TGF-beta1 and Tbeta II R in the kidneys of the rats.
RESULTS:Compared with the normal control group, both the mRNA and protein expression of TGF-beta1 and Tbeta II R in the diabetic rat group and treatment group were significantly increased (P < 0.05). Compared with the diabetic rat group, simvastatin could markedly decrease the mRNA and protein expression of TGF-beta1 and Tbeta II R (P < 0.05).
CONCLUSION:Simvastatim may play a protective role in the diabetic kidneys by down-regulating TGF-beta1 and Tbeta II R and inhibiting the TGF-beta signal pathway.
