Expression of brain-derived neurotrophic factor in hippocampus of ovariectomized mouse.
- Author:
Da-hua LU
1
;
De-sen YANG
;
Dan LIU
;
Chang-qi LI
;
Xue-gang LUO
Author Information
1. Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Brain-Derived Neurotrophic Factor;
biosynthesis;
genetics;
Dentate Gyrus;
metabolism;
Estrogens;
blood;
Female;
Hippocampus;
metabolism;
Mice;
Ovariectomy;
RNA, Messenger;
biosynthesis;
genetics
- From:
Journal of Central South University(Medical Sciences)
2005;30(1):53-56
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus after ovariectomy in mice.
METHODS:BDNF levels were detected by immunohistochemistry combined image analysis in hippocampal CA regions and dentate gyrus of ovariectomized mice.
RESULTS:The expression of BDNF in hippocampus of mice decreased significantly after the ovariectomy after 4 days. The recovery BDNF expression started 14 days after the ovariectomy and after 28 days, the expression of BDNF in hippocampus recovered to the normal level.
CONCLUSION:The decrease of estrogen in ovariectomized mice can weaken the expression of BDNF in hippocampus during the early stage.
