Expression of cylooxygenase-2 in endometriosis.
- Author:
Hong FAN
1
;
Xiao-ling FANG
Author Information
1. Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, Changsha, China. fanwentao2002@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adult;
Cyclooxygenase 2;
biosynthesis;
genetics;
Endometriosis;
enzymology;
Endometrium;
enzymology;
Female;
Humans;
Immunohistochemistry;
Ovarian Diseases;
enzymology
- From:
Journal of Central South University(Medical Sciences)
2005;30(1):92-95
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of cyclooxygense-2 (COX-2) in eutopic and ectopic endometrium in ovarian endometriosis.
METHODS:Thirty patients with ovrian endometriosis, 10 with ovarian chocolate cysts and 27 normal controls were enrolled it determine the expression of COX-2 immunohistochemically in eutopic or ectopic endometrium or healthy endometrial tissues.
RESULTS:The immunoreactivities of COX-2 were found in epithelial cells and stromal cells in eutopic endometrium. The expression of COX-2 in the epithelial cells in the secretory phase was higher than that in the proliferative phase in the control group and ovarian endometriosis group (P <0. 05). But the expression of COX-2 in stromal cells in the control group and ovarian endometriosis group showed no cyclic changes throughout the menstrual cycle (P > 0. 05). The expression of COX-2 in eutopic and ectopic endometrium in the ovarian endometriosis group was higher than that in the control group (P <0. 05) , hut we did not find significant difference between the eutopic and ectopic endometrium in the ovarian endometriosis group (P > 0. 05).
CONCLUSION:The increased COX-2 expression in eutopic and ectopic endometrium in ovarian endometriosis may he related to its pathology.
