Experimental study of spirulina platensis in treating allergic rhinitis in rats.
- Author:
Li-lan CHEN
1
;
Shi-fu ZHANG
;
Di-nan HUANG
;
Ji-quan TAN
;
Sheng-hua HE
Author Information
1. Department of Otorhinolaryngology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Eukaryota;
Male;
Ovalbumin;
Phytotherapy;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Rhinitis, Allergic, Perennial;
chemically induced;
drug therapy
- From:
Journal of Central South University(Medical Sciences)
2005;30(1):96-98
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the therapeutic effect of spirulina platensis in allergic rhinitis (AR).
METHODS:Ovalbumin sensitized white rats used as AR animals were treated with spirulina platensis (SPP). At the end of the treatment, the differences in the behavior science were observed; the changes in the nasal mucosa and mast cell degranulation were studied pathologically; and the levels of serum histamine and total immunoglobulin (Ig) E were determined by enzyme-linked immune sorbent assay.
RESULTS:The behavior science score of the SPP treatment group was lower than that of the negative control group (P < 0.01 ) ; inflammatory reaction of nasal mucosa in the SPP treatment group were remarkably relieved; the number of nasal mucosa mastocyte and mast cell degranulation in the SPP treatment group were lower than that of the negative control group (P <0.01 ). The levels of serum histamine and total IgE in the SPP treatment group were lower than that of the negative control group (P <0.01 ). It had no significant difference in the positive control group and the SPP treatment group and the blank control group (P > 0.05 ).
CONCLUSION:Spirulina platensis can prevent and treat AR in rats, which implies the possibility of using spirulina platensis for AR patients in the future.
