Expression of matrix metalloproteinase 2 in oral verruvous carcinoma and squamous cell carcinoma.
- Author:
Zhan-gui TANG
1
;
Jin-mao LI
;
Zhen-zhen HONG
;
Zhi-wei YU
;
Cheng-hui LIU
Author Information
1. Departerment of Oral and Maxillofacial Sturgery, Xiangya Hospital, Central South University, Changsha 410008, China. Tangzhangui@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adult;
Carcinoma, Squamous Cell;
enzymology;
Carcinoma, Verrucous;
enzymology;
Female;
Humans;
Male;
Matrix Metalloproteinase 2;
biosynthesis;
genetics;
Middle Aged;
Mouth Neoplasms;
enzymology;
RNA, Messenger;
biosynthesis;
genetics
- From:
Journal of Central South University(Medical Sciences)
2005;30(6):650-652
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the expression of MMP2 mRNA in oral verruvous carcinoma and squamous cell carcinoma.
METHODS:Thirty cases were divided into 3 groups: verruvous carcinoma (n = 10), well-differentiated squamous cell carcinoma (n = 15) and moderately or poorly differentiated squamous cell carcinoma (n = 5). Reverse transcription polymerase chain reaction (RT-PCR) was used to test the expression of MMP2 mRNA in the carcinoma tissues and matched normal tissues from 3 groups above.
RESULTS:The expression of MMP2 mRNA in the carcinoma tissues was significantly higher than that in their matched normal tissues (P < 0.05). The expression of MMP2 mRNA in verruvous carcinoma was significantly higher than that in well-differentiated and moderately or poorly differentiated squamous cell carcinoma (P < 0.05). However, the expression of MMP2 mRNA was not obviously different between well-differentiated and moderately or poorly differentiated squamous cell carcinoma (P > 0.05).
CONCLUSION:The expression of MMP2 mRNA in oral verruvous carcinoma and squamous cell carcinoma tissues was significantly higher than that in their matched normal tissues. The expression of MMP2 mRNA in verruvous carcinoma was significantly higher than that in squamous cell carcinoma.
