Effects of nasal continuous positive airway pressure short-term treatment on C-reactive protein and intercellular adhesion molecule-1 in patients with obstructive sleep apnea-hypopnea syndrome.
- Author:
Yi-na WANG
1
;
Yu YANG
;
Ying-quan LUO
;
Long-long CHEN
Author Information
1. Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China. angela780415@163.net
- Publication Type:Journal Article
- MeSH:
Adult;
C-Reactive Protein;
metabolism;
Continuous Positive Airway Pressure;
methods;
Female;
Humans;
Intercellular Adhesion Molecule-1;
metabolism;
Male;
Sleep Apnea, Obstructive;
blood;
therapy;
Time Factors
- From:
Journal of Central South University(Medical Sciences)
2005;30(6):666-669
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investgate the effects of nasal continuous positive airway pressure (nC-PAP) short-term treatment on the serum level of C-reactive protein (CRP) and intercellular adhesion molecule-1 in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients.
METHODS:Twenty patients with OSAHS ( AHI > or = 15 ) and 15 controls (AHI < 15) were recruited. After polysomnography (PSG), the venous blood was collected from all subjects to investigate CRP and ICAM-1. The effects of short-term treatment (4 d) of nCPAP on the serum levels of CRP and ICAM-1 were studied in patients with moderate and severe OSAHS.
RESULTS:Before the treatment, there was a significant positive correlation between CRP and AHI in all subjects (r = 0.615, P < 0.001), a significant negative correlation between CRP and the mean nocturnal oxygen saturation (r = -0.682, P < 0.001), and a significant negative correlation between CRP and the lowest nocturnal SaO2 (r = -0.61, P < 0.001). There was a significant positive correlation between ICAM-1 and AHI in all subjects (r = 0.751, P < 0.001), a significant negative correlation between ICAM-1 and the mean nocturnal oxygen saturation (r = -0.68, P < 0.001), and a significant negative correlation between ICAM-1 and the lowest nocturnal oxygen saturation (r = -0.656, P < 0.001). There was a significant positive correlation between CRP and ICAM-1 (r = 0.437, P = 0.009). The levels of CRP and ICAM-1 were significantly higher in patients with moderate and severe OSAHS than in the controls (P < 0.01). nCPAP decreased the levels of CRP and ICAM-1 in patients with moderate and severe OSAHS (P < 0.01).
CONCLUSION:Inflammatory reaction exists in OSAHS and can be palliated after nCPAP short-term treatment.
