Protective effects of ulinastatin on the lung injury during cardiopulmonary bypass.
- Author:
Dian-jun WANG
1
;
Jian-xin LIU
;
Bang-liang YIN
Author Information
1. Department of Cardiothoracic Surgery, Third Xiangya Hospital, Central South University, Changsha 410013 China. wangdianjun5128@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Bronchoalveolar Lavage Fluid;
Cardiopulmonary Bypass;
Female;
Glycoproteins;
therapeutic use;
Humans;
Leukocyte Elastase;
metabolism;
Male;
Middle Aged;
Protective Agents;
therapeutic use;
Respiratory Distress Syndrome, Adult;
prevention & control;
Rheumatic Heart Disease;
surgery;
Trypsin Inhibitors;
therapeutic use;
Tumor Necrosis Factor-alpha;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2005;30(6):670-672
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the protective effects and mechanism of ulinastatin on the lung injury during cardiopulmonary bypass (CPB).
METHODS:Thirty patients with rheumatic heart disease (RHD) were divided into 2 groups randomly. The ulinastatin group (Group U, n = 15) received 1 x 10(4)U/kg ulinastatin intravenously before the CPB and the same amount of ulinastatin was added into the primary solution. The control group (Group C,n = 15) received normal saline instead of ulinastatin. A brochioalveolar lavage was performed at 2 h after the cardiopulmonary bypass. Polymorphonuclear neutrophil elastase, tumor necrosis factor-alpha and MDA contents in the brochioalveolar lavage fluids were measured, and the lung oxygenate index was measured preoperatively and at 1 and 4 h after CPB termination.
RESULTS:Polymorphonuclear neutrophil elastase, tumor necrosis factor-alpha and MDA contents of Group U in the brochioalveolar lavage fulids were significantly lower than those of Group C (P < 0.05), and the lung oxygenate index of Group U at 1 and 4 h after CPB termination was also significantly lower than that of Group C. A significant increase of lung oxygenate index occurred in both groups at 1 and 4 h after CPB when compared with the same group at the baseline before CPB (P < 0.05).
CONCLUSION:Ulinastatin has the protective effects on the lung injury during CPB by decreasing polymorphonuclear neutrophil elastase, alleviating lung inflammatory reaction and reducing oxygen free radicals.
