Diagnostic value of the detection of aromatase cytochrome P450 and CA125 for endometriosis.
- Author:
Fei ZENG
1
;
Min XUE
Author Information
1. Department of Obstetrics and Gynecology, Third Xiangya Hospital, Central South University, Changsha 410013, China. zengfeilyx@163.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aromatase;
analysis;
Biopsy, Needle;
CA-125 Antigen;
analysis;
Endometriosis;
diagnosis;
Endometrium;
chemistry;
Female;
Humans;
Sensitivity and Specificity
- From:
Journal of Central South University(Medical Sciences)
2005;30(6):682-685
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the diagnostic value of examining endometrial biopsy specimens for aromatase cytochrome P450 and CA125 for endometriosis.
METHODS:The expression of aromatase cytochrome P450 in endometrium was detected by immunohistochemical analysis for 36 endometriosis women and 22 non-endometriosis but subfertility or pelvic pain women served as controls; the serum CA125 levels were measured by chemical radiation method.
RESULTS:By measuring serum CA125, the sensitivity of the serum CA125 assay was 44%, the specificity was 82%, the positive predictive value was 80%, and the negative predictive value was 47%; the sensitivity of aromatase cytochrome P450 in biopsy endometrium of endometriosis was 82%, the specificity was 59%, the positive predictive value was 76%, and the negative predictive value was 67%.
CONCLUSION:The combination assay of aromatase cytochrome P450 in eutopic endometrium and CA125 can be used as a diagnostic test for endometriosis, especially for the early stage of endometriosis, which is superior to the assay of CA125.
