Correlation between dynamic contrast-enhanced MRI and expression of microvascular density in the glioma.
- Author:
Dan YIN
1
;
Xiao-yi WANG
;
Xue-bin YAN
;
Wei-hua LIAO
Author Information
1. Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China). yindan3418@126.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Brain Neoplasms;
blood supply;
Child;
Contrast Media;
Female;
Gadolinium;
Glioma;
blood supply;
Humans;
Image Enhancement;
methods;
Magnetic Resonance Imaging;
instrumentation;
methods;
Male;
Microcirculation;
Middle Aged;
Neovascularization, Pathologic
- From:
Journal of Central South University(Medical Sciences)
2005;30(6):686-689
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the correlation between microvascular density (MVD) and dynamic contrast-enhanced MRI in the glioma.
METHODS:We examined 35 patients with histologically verified glioma. Gadolinium-enhanced dynamic TurboFLASH imaging was performed preoperatively in all patients followed by conventional MRI. The steepest slope (SSmax) of curve and corresponding Tm1 in "first-pass" phase were obtained by analyzing time-signal curve. All specimens were immunostained with anti-human Factor VIII relative antigen monoclonal antibody postoperatively by streptavidin-peroxidase method to obtain the MVD. The correlation between SSmax, Tm1, and MVD was analyzed.
RESULTS:SSmax was positively correlated with MVD (r = 0.640, P < 0.01). Tml was negatively correlated with MVD (r = -0.671, P < 0.01).
CONCLUSION:The MVD correlates obviously with SSmax and Tml in the glioma. Analyzing the time-signal curve of dynamic contrast-enhanced MRI is helpful to predict the angiogenesis in the glioma.
