Expression and significance of PTEN and nm23 in the metastasis of gallbladder cancer.
- Author:
Chang-Li ZHENG
1
;
Ji-Fang WEN
;
Ying HUANG
Author Information
1. Department of Pathology, Xiangya School of Medicine, Central South University, Changsha 410078, China.
- Publication Type:Journal Article
- MeSH:
Female;
Gallbladder Neoplasms;
metabolism;
Humans;
Liver Neoplasms;
metabolism;
secondary;
Lymphatic Metastasis;
Male;
NM23 Nucleoside Diphosphate Kinases;
Nucleoside-Diphosphate Kinase;
biosynthesis;
genetics;
PTEN Phosphohydrolase;
biosynthesis;
genetics;
Tumor Suppressor Proteins;
biosynthesis;
genetics
- From:
Journal of Central South University(Medical Sciences)
2005;30(1):46-48
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the relationship between the expressions of PTEN and the metastasis of the gallbladder cancer.
METHODS:The expression of PTEN and nm23 were detected by immunohistochemical staining in 32 cases of gallbladder cancer with metastasis and the staining intensity was scored semi-quantitatively, compared with the cases without metastasis.
RESULTS:The intensity score of PTEN and nm23 in gallbladder cancer with metastasis was 8.9947+/-4.5590 and 10.2003+/-3.9031, respectively, which was lower than that in those without metastasis (12.9433+/-4.7618 and 15.8436+/-5.6917 respectively, P < 0.01 ). The expression of PTEN was correlative with that of nm23 ( Pearson = 0.370, P < 0.05).
CONCLUSION:The lower expressions of PTEN and nm23 are related to the metastasis of gallbladder cancer.
