Metabolic Syndrome and Benign Prostatic Hyperplasia: Evidence of a Potential Relationship, Hypothesized Etiology, and Prevention.
10.4111/kju.2011.52.8.507
- Author:
Firas ABDOLLAH
1
;
Alberto BRIGANTI
;
Nazareno SUARDI
;
Fabio CASTIGLIONE
;
Andrea GALLINA
;
Umberto CAPITANIO
;
Francesco MONTORSI
Author Information
1. Department of Urology, San Raffaele Hospital, Universita Vita-Salte, Urological Research Institute (URI), Milan, Italy. firas.abdollah@gmail.com
- Publication Type:Review
- Keywords:
Insulin resistance;
Metabolic syndrome X complications;
Obesity complications;
Prostatic hyperplasia etiology;
Prostatic hyperplasia pathology
- MeSH:
Dyslipidemias;
Gonadal Steroid Hormones;
Humans;
Hypertension;
Incidence;
Insulin;
Insulin Resistance;
Lower Urinary Tract Symptoms;
Male;
Motor Activity;
Prostatic Hyperplasia;
rho-Associated Kinases
- From:Korean Journal of Urology
2011;52(8):507-516
- CountryRepublic of Korea
- Language:English
-
Abstract:
Benign prostatic hyperplasia (BPH) is highly prevalent in older men and causes substantial adverse effects on health. The pathogenesis of this disease is not totally clear. Recent reports have suggested a possible relationship between metabolic syndrome (MetS) and BPH. Single components of MetS (obesity, dyslipidemia, hypertension, and insulin resistance) as well as the syndrome itself may predispose patients to a higher risk of BPH and lower urinary tract symptoms (LUTS). This may stem from changes in insulin resistance, increased autonomic activity, impaired nitrergic innervation, increased Rho kinase activity, pro-inflammatory status, and changes in sex hormones that occur in association with MetS. However, the exact underlying mechanisms that regulate the potential relationship between MetS and BPH/LUTS still need to be clarified. Increased physical activity and dietary strategies may help in decreasing the incidence of MetS and its impact on BPH/LUTS. However, differences in the definitions used to address the examined predictors and endpoints preclude the possibility of arriving at definitive conclusions.
