Myocardial protective effects of pretreatment with captopril on ischemia-reperfusion myocardium in rabbits.
- Author:
Ming-song HU
1
;
Jian-guo HU
;
Xin-min ZHOU
;
Yao-guang FENG
;
Hui WANG
;
Jin-fu YANG
Author Information
1. Department of Cardiothoracic Surgery, Second Xiangya Hospital ,Central South University , Changsha 410011, China. humingsong1973@hotmail.com
- Publication Type:Journal Article
- MeSH:
Animals;
Captopril;
pharmacology;
therapeutic use;
Endothelins;
blood;
Male;
Myocardial Infarction;
blood;
drug therapy;
Myocardial Reperfusion Injury;
prevention & control;
Myocardium;
ultrastructure;
Nitric Oxide;
blood;
Rabbits;
Random Allocation
- From:
Journal of Central South University(Medical Sciences)
2005;30(2):211-214
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of pretreatment with captopril on myocardium ischemia-reperfusion injury in atherosclerotic rabbits.
METHODS:Thirty-two New Zealand white rabbits were assigned randomly to the normally feed group, cholesterol-feed (CF) group, and cholesterol food plus captopril group (cap-feed group), which were fed for 10 weeks. We examined the changes in the size of the infarct and changes in the myocardium ultrastructure resulting from coronary ischemia/reperfusion. Levels of endothelin (ET) and nitic oxide (NO) were measured in the different experiment stages.
RESULTS:The ET levels significantly increased and the content of NO significantly decreased in the CF group compared with those of the cap-feed group. The ultrastructure of myocardium cell was slightly destroyed and the infarct size was significantly smaller in the cap-feed group than the normally feed rabbits and CF rabbits.
CONCLUSION:The long-term captopril treatment can lighten the severity of myocardial injury produced by coronary ischemia/reperfusion.
